Headlines

Ordinary Skin Cells Morphed into Functional Brain Cells

Paul Tesar, PhD at Case Western Reserve School of Medicine has discovered a technique that directly converts skin cells to the type of brain cells destroyed in patients with multiple sclerosis, cerebral palsy and other so-called myelin disorders. This discovery appears in the journal Nature Biotechnology.
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Plan to attend MSC 2013 August 19-21, 2013 in Cleveland, OH

Online registration for MSC 2013: Adult Stem Cell Therapy and Regenerative Medicine is open and poster abstracts are being accepted for presentation both in poster format and potentially for podium presentation during the main program as well. MSC 2013 will offer a forum for the exchange and discussion of research, ideas, and cutting-edge breakthroughs in translational regenerative medicine. The breadth of topics from basic discovery through model validation, clinical product development, and therapeutic application, in addition to the links between academic and commercial labs, make this conference imperative for industrial researchers, academic investigators, IP and regulatory specialists, biotechnology development investors and post-doctoral and graduate students.

Learn about stem cells!

Join over 8 million users and learn about how stem cells are being used in the laboratory and in the hospital. The NCRM teamed up with Edheads, a provider of online education tools, to launch 3 web-based education modules about stem cells. The modules, based on real clinical trials, are geared toward high school students and designed to enhance classroom curriculum. They offer a highly innovative and interactive learning experience to demonstrate the nature of stem cells and their importance in medicine and the development of new therapies.

Click here for Activity 1
Click here for Activity 2
Click here for Activity 3

NCRM Receives Ohio Third Frontier Grant for Therapeutic Cell Center

The Ohio Third Frontier Commission unanimously awarded Case Western Reserve University National Center for Regenerative Medicine (NCRM), $2.4 million for its OH-Alive Innovator Platform: A Process and Manufacturing Platform for Cell Therapy. These funds must be matched by NCRM and its collaborators so this represents a total investment of $4.8 million. The OH-Alive platform will help advance Ohio as one of the leading regions for stem cell therapy in the country by establishing a facility that will provide expertise in determining optimized conditions for producing stem cells for therapeutic purposes. Read more

News

May 06, 2013
Stem cells found to cure epilepsy in mice
Link to article

April 12, 2013
“First-in-humans” trial with cardiopoietic stem cells shows promising results
Link to article

April 01, 2013
Tengion Receives MPA Approval of CTA for Neo-Kidney Augment Phase 1 Trial in Sweden
Link to article

March 28, 2013
Multi-million-dollar stem cell bank will be based at Buck Institute in Novato
Link to article

March 28, 2013
ReNeuron signs 'landmark' pact to advance stem cell line
Link to article

more news...

Press Releases

May 06, 2013
New material system permits 3-D patterning to regulate stem cell behavior
Link to article

April 14, 2013
Ordinary skin cells morphed into functional brain cells
Link to article

March 21, 2013
National Center for Regenerative Medicine has 3 of the Top 50 Stem Cell Influencers
Link to article

March 12, 2013
Stem cell company Athersys expects more R&D spending, potential partnerships in 2013 Read more: http://medcitynews.com/2013/03/stem-cell-company-athersys-expects-more-rd-spending-potential-partnerships-in-2013/#ixzz2PKtn1VxR
Link to article

February 28, 2013
Small Companies Are Hubs of Future Profit in Regenerative Medicine: Gil Van Bokkelen
Link to article

more press releases...

Cleveland skyline
All Researchers

A - C
D - F
G - I
J
K - L
M
N - Q
R - T
U - Z

Investigator Expertise Therapeutic Area
A. Ahmady, UHCMC
Publications
Adult and embryonic stem cell derivation and differentiation Reproduction & Gender based disorders
A. Askari, UHCMC
Publications
Myocardial vascular repair Cardiovascular
A. Caplan, CWRU
Publications
Tissue engineering of mesenchymal tissue, skeletal tissue biology, ECM, and skin aging Musculoskeletal
A. Hijaz, UHCMC
Publications
Homing of MSCs for urinary incontinence Reproduction & Gender based disorders
A. Rollins, CWRU
Publications
Optical coherence tomography to image tissue microstructure and function Imaging
A. Sen Gupta, CWRU, UHCMC
Publications
Targeted nanomedicine & molecular imaging for cardiovascular & cancer pathology Biology & Immunology
A. Sloan, CWRU, UHCMC
Publications
Treatment modalities for gliomas as well as outcome measurements of various therapies Oncology
A. Ting, Athersys
Publications
MAPCs for myocardial regeneration Cardiovascular
B. Anand-Apte, CC
Publications
Ocular angiogenesis Sensory
B. Kaspar, OSU
Publications
Gene delivery and stem cell biology in the central nervous system Neurology
B. Trapp, CC
Publications
Neurodegenerative diseases, multiple sclerosis Neurology
C. McDevitt, CC
Publications
Cell-matrix interactions in the repair of connective tissues Musculoskeletal
C. O’Keefe , CC
Publications
Genomic damage in HSC Biology & Immunology
C. Qu, CWRU
Publications
Signaling mechanisms of hematopoietic cell processes Oncology
D. Janigro, CC
Publications
Stroke and cerebrovascular damage Neurology

D. Ramirez-Bergeron, CWRU
Publications

Role of hypoxia in cardiovascular development Cardiovascular
D. Simon, Case, UHCMC
Publications
Developing new approaches to targeting restenosis of arteries Cardiovascular
D. Wilson, CWRU
Publications
Minimally invasive, interventional medical imaging Imaging
E. Alsberg, CWRU
Publications
Cell-instructive biomaterials, drug delivery, musculoskeletal engineering Musculoskeletal
E. Lavik, CWRU
Publications
Translatable approaches to treat injuries and diseases of the central nervous system Neurology
E. Greenfield, UHCMC
Publications
Bone regeneration from progenitors Musculoskeletal
F. Lin, CWRU
Publications
Developing novel reagents to fight autoimmune disease Biology & Immunology
G. Grossman, CWRU, UHCMC
Publications
Neuro-muscular disorders, neuro-opthamology, neuro-physiology Neurology
G. Muschler, CC
Publications
Bone tissue engineering, osteoblastic differentiation, changes in CTPs Musculoskeletal
G. Wnek, CWRU
Publications
Polymeric materials for retina and cornea regeneration Sensory
G. Zhang, UA
Publications
Directing vascular and neuronal differentiation from stem cells Neurology
H. Baskaran, CWRU
Publications
Transport mechanisms in biology and medicine for tissue engineering Musculoskeletal
H. Das, OSU
Publications
Regulating factors involved in inflammation activation and cardiomyocytes Oncology
H. Lazarus, UHCMC
Publications
Clinical MSC and HSC transplantation Cardiovascular
H. Lee, CWRU
Publications
Neurodegenerative diseases; Alzheimers disease Neurology
H. Suh, CC
Publications
Adult neural stem cells and their roles in the normal brain functions and disease pathology Neurology
H. von Recum, CWRU
Publications
Tissue engineering blood vessels Cardiovascular
J. Auletta, CWRU, UHCMC
Publications
Antigen presenting cells and MSC in immunomodulation Biology & Immunology
J. Cohen, CC
Publications
Use of adult stem cells to treat multiple sclerosis Neurology
J. Dennis, CWRU
Publications
Laboratory Site
MSC culture, differentiation and histology Musculoskeletal
J. Duerk, CWRU, UHCMC
Publications
Imaging core for all in vivo modeling, especially HSC, MSC Imaging
J. Fulton, AGMC
Publications
Wound healing using progenitors and tissue engineered scaffolds Dermatology
J. Harrington, Athersys
Publications
Technology development, novel drug target identification Oncology
J. Jacobberger, CWRU
Publications
Flow imaging of stem cell survival and differentiation Biology & Immunology
J. Jensen, CC
Publications
Developmental biology of pancreatic insulin-producing cells Diabetes
J. Lee, CC
Publications
Molecular pathways critical for glioblastoma (GBM) pathogenesis for therapeutic strategies Oncology
J. Liu, CWRU, UHCMC
Publications
Reproductive endocrinology and infertility and in vitro fertilization Reproduction & Gender based disorders
J. Maciejewski, CC
Publications
Stem cell failure syndromes Biology & Immunology
J. Navia, CC
Publications
Heart disease and surgical techniques Cardiovascular
J. Prologo, UHCMC, CWRU
Publications
Image guided delivery of stem cells Imaging
J. Rich, CC
Publications

Glioma stem cell and brain tumor malignancy, signal transduction pathways in brain tumors, and small molecule inhibitors and brain cancer treatments

Oncology
J. Sanabria, UHCMC
Publications
Hepatobiliar surgery and kidney, pancreas and liver transplants Diabetes
J. Silver, CWRU
Publications
Spinal cord injury and repair Neurology
J. Wells, Univ. Cincinnati
Publications
Pancreas, biliary and intestinal development in vivo and from stem cells. Biology & Immunology
J. Welter, CWRU
Publications
Optimizing the chondrogenic potential of adult MSCs; bioreactor design Musculoskeletal
K. Alagramam, CWRU,
UHCMC

Publications
Genes to develop, protect and regenerate sensory hair cells Sensory
K. Asosingh, CC
Publications
Stem cell biology in lung disease Biology & Immunology
K. Bunting, UHCMC
Publications
Stem Cell Signaling in HSCs Biology & Immunology
K. Cooke, CWRU, UHCMC
Publications
Graft versus Host Disease and lung injury after BMT Biology & Immunology
K. Cooper, CWRU, UHCMC
Publications
Skin remodeling with progenitors Dermatology
K. Laurita, CWRU, MetroHealth
Publications
Cell therapy for sudden cardiac death Cardiovascular
K. Lu, CWRU, UHCMC
Publications
Macrophages in wound healing and regeneration Dermatology
K. McLaughlin, OSU
Publications
Pluripotent stem cell biology and genomic imprinting Biology & Immunology
K. Molyneaux, CWRU
Publications
Development of the mammalian gonad Reproduction & Gender based disorders
K. Tamama, OSU
Publications
MSC biology, self-renewal, hypoxic condition Cardiovascular
L. Lasky, OSU
Publications
UCB expansion and bioreactor design Biology & Immunology
L. Solchaga, CWRU
Publications
Cell-based tissue engineering with MSC and musculoskeletal tissues Musculoskeletal
M. Costa, CWRU, UHCMC
Publications
Stenting and vascular study of diabetic patients Cardiovascular
M. Damaser, CC
Publications
Biomechanics and neuromuscular control of the lower urinary tract and female pelvic floor Reproduction & Gender based disorders
M. Ishikawa, CWRU
Publications
Cell-assisted organogenesis in orthopaedic fields Musculoskeletal
M. Jain, CWRU, UHCMC
Publications
Regulating factors involved in antithrombotic endothelial surfaces Cardiovascular
M. Knothe-Tate, CWRU
Publications
Cell-based tissue engineering for bone repair Musculoskeletal
M. Laughlin, CWRU,
UHCMC

Publications
UCB for hematopoietic and vascular regeneration, transplantation Oncology
E. Medof, CWRU
Publications
Pathology, stem cell biology Biology & Immunology
M. Mesarovic, CWRU
Publications
Systems biology and mathematical modeling Biology & Immunology
M. Parat, CC
Publications
Endothelial cell migration and angiogenesis in breast cancer Oncology
Ma, Patrick, CC
Publications
Lung and Esophageal Cancers, Thoracic Cancer, Translational Clinical research in Thoracic Oncology Oncology
M. Penn, CC
Publications
Myocardial regeneration and repair Cardiovascular
M. Siemionow, CC
Publications
Intraosseous BMT transplantation for induction/ maintenance of tolerance Biology & Immunology
M. Sorrell, CWRU
Publications
Non-invasive diagnostics using monoclonal antibody technology Musculoskeletal
M. Veigl, CWRU
Publications
Mutagenesis by chemotherapeutic agents Oncology
M. Zborowski, CC
Publications
Separation processes for medical applications Musculoskeletal
M. Zutshi, CC
Publications
Stem cell therapy for fecal incontinence and pelvic floor disorder Reproduction & Gender based disorders
N. Greco, CWRU, UHCMC
Publications
AC133 umbilical cord blood derived stem cells for angiogenesis Cardiovascular
N. Harter, CWRU
Publications
Pathways for cell cycle restoration in skeletal muscle cells Musculoskeletal
N. Moldovan, OSU
Publications
Cellular cooperation, plasticity and biomechanical factors in angiogenesis Cardiovascular
N. Rote, CWRU, UHCMC
Publications
Reproductive immunology and human trophoblast differentiation Reproduction & Gender based disorders
N. Sizemore, CC
Publications
Gene expression, oncogenesis, and apoptosis in cancer Oncology
N. Smedira, CC
Publications
Heart transplantation and ventricular assist devices Cardiovascular
N. Sreenath, CWRU
Publications
Signal transduction in cancer and inflammation Oncology
N. Waheed, CC
Publications
HSCs to treat retinopathy Sensory
N. Ward, CWRU, UHCMC
Publications
Tissue neurovasculature development Dermatology
P. DiCorleto, CC
Publications
Endothelial cell function, vascular cell signaling/gene expression Cardiovascular
P. Karnik, CWRU
Publications
Hair follicle stem cells, cicatricial alopecia and hair follicle regeneration Dermatology
P. Parsons, NASA
Publications
Measurement of blood vessel growth and remodeling Cardiovascular
P. Tesar, CWRU
Publications
Embryonic stem cells, pluripotency, and regeneration Biology & Immunology
Q. Kong, CWRU
Publications
Prion protein in prion & muscle diseases; muscle stem cell therapy Musculoskeletal
R. Atit, CWRU
Publications
Dermal precursor from MSC Dermatology
R. Beck, CWRU
Publications
Immunology of Bone Marrow Transplantation Biology & Immunology
R. Deans, Athersys
Publications
MAPCs for myocardial regeneration Cardiovascular
R. Mays, Athersys
Publications
MAPCs used to treat neurological diseases Neurology
R. Midura, CC
Publications
Connective tissue biology; regulation of bone and cartilage formation Musculoskeletal
R. Miller, CWRU
Publications
Spinal cord diseases and oligodendrocyte repair Neurology
R. Perry, Athersys
Publications
MAPCs for myocardial regeneration Cardiovascular
S. Bao, CC
Publications
Regulation of stem cell properties in glioma stem cells and neural stem cells Oncology
S. Bhakta, CWRU, UHCMC
Publications
Cardiovascular stem cell therapy Cardiovascular
S. Ellis, CC
Publications
Stenting, therapeutic angiogenesis and coronary revascularization Cardiovascular
S. Gerson, CWRU, UHCMC
Publications
Stem cell gene transfer, drug selection, transdifferentiation Oncology
S. Haynesworth, CWRU
Publications
MSC characterization and stromal support Musculoskeletal
S. Qian, CC
Publications
Development of stem cells for islet transplantation Biology & Immunology
S. Valadkhan, Univ. Cincinnati
Publications
Reprogramming of mesodermal cells into neurons by a long non-coding RNA Biology & Immunology
T. Bonfield, CWRU
Publications
Stem cells and airway inflammation Biology & Immunology
T. Hering, CWRU
Publications
Cartilage chondrocyte biology Musculoskeletal
T. McCormick, CWRU, UHCMC
Publications
Regulation of innate and adaptive immunity in skin and epithelia Dermatology
V. Pompili, OSU
Publications
Myocardial vascular repair Cardiovascular
W. Tse, UC
Publications
Lymphoma, leukemia, and multiple myeloma Oncology
W. Van’t Hof, Athersys
Publications
MAPCs for myocardial regeneration Cardiovascular
Y. Elgudin, CWRU, UHCMC
Publications
Circulatory support, biological tissue substitutes and tissue engineering Cardiovascular
Y. Kim, CC
Publications
Transcriptional regulation of pancreatic endocrine progenitors Diabetes
Y. Yang, CWRU
Publications
Cytokine signal transduction Oncology
Y. Yun, UA
Publications
Tissue engineering scaffolds for gene drug delivery Biology & Immunology
Z. Ashraf, CC
Publications
Endothelial progenitor cells, vascular gene regulation, and lipid metabolism Cardiovascular
Z. Lee, UHCMC
Publications
Imaging core for all in vivo modeling, especially HSC, MSC Imaging

CC = Cleveland Clinic, CWRU = Case Western Reserve University, OSU = The Ohio State University, UHCMC = University Hospitals Case Medical Center